Medusa Cucina Siciliana

4.7(172)· Google4.7 out of 5 from 172 reviews (Google rating)Italian Restaurant Midtown
Closed · opens 4 PM

Quick facts

Medusa Cucina Siciliana is a italian restaurant at 644 Selden St in Detroit, MI, open Sun, Mon, Wed, Thu, Fri and Sat. takeout, dine-in and reservations available.

Address
644 Selden St, Detroit, MI 48201
Phone
(313) 798-3498
Hours today
4 PM–11:30 PM
Accessibility
Wheelchair accessible entrance

About Medusa Cucina Siciliana

Medusa Cucina Siciliana is a women-owned Italian restaurant at 644 Selden St in Detroit, MI, with a focus on Sicily’s culinary heritage. The restaurant describes its approach as drawing on the influences left by the island’s different rulers. Dinner is a main draw, with small plates, comfort food, vegan and vegetarian options, and dessert among the listed offerings. An on-site bar serves cocktails, wine, beer, and liquor; coffee and late-night food are also available.

The setting combines casual, cozy, and upscale elements, with a romantic atmosphere. Medusa welcomes families and groups, is suitable for solo dining, and identifies as LGBTQ-welcoming and a transgender safe space. Reservations are accepted, and a private dining room and outdoor seating are available. Guests can dine in with table service or order takeout, but delivery is not offered. The entrance, restroom, and seating are wheelchair accessible. Paid street parking is available, though wheelchair-accessible parking is not listed.

Around Medusa Cucina Siciliana in Detroit, MI

Upcoming events nearby

Known for

  • Sicilian culinary focus
  • Cocktails, wine, and coffee
  • Vegan and vegetarian options
  • Private dining and outdoor seating
  • Women-owned, LGBTQ-welcoming restaurant

Good for

What reviewers say elsewhere

  • “OMG, the flavors! Wife and I both did the chef's tour option, everything was spectacular, but we were both full before the entree even arrived. Well, full, but still we both ate the amazing custard 🍮!”

    — Sam Smalley, October 8, 2026 · google

  • “Service was slow on a night that wasnt busy. Food was unique in concept, very creative, but simply didn't meet expectations. Pastas were salty. Brioche was hard. Atmosphere, however, is spot on. Beautiful space.”

    — Sandra Elliott, October 7, 2026 · google

  • “Absolutely marvelous dinner will come again”

    — Mary McMann, October 5, 2026 · google

  • “Food was delicious, our waiter was very accommodating and gave his recommendations! The cannoli cart was amazing ! Would highly recommend.”

    — Roman Hnatiuk, September 26, 2026 · google

Excerpts are shown for attribution and remain the property of their source.

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Within walking distance

Medusa Cucina Siciliana — frequently asked

Is Medusa Cucina Siciliana open on Mondays?
Yes — Medusa Cucina Siciliana is open Monday, 5 PM–11 PM.
Where is Medusa Cucina Siciliana?
Medusa Cucina Siciliana is at 644 Selden St, Detroit, MI 48201.
Does Medusa Cucina Siciliana do takeout or delivery?
According to its Google listing, Medusa Cucina Siciliana offers takeout and does not offer delivery.
Does Medusa Cucina Siciliana take reservations?
Yes — Medusa Cucina Siciliana accepts reservations.
What is the phone number for Medusa Cucina Siciliana?
You can reach Medusa Cucina Siciliana on (313) 798-3498.

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